Celery Seed Extract: A Natural Calcium Channel Blocker

Celery Seed Extract: A Natural Calcium Channel Blocker

Celery is a simple food with a complex chemical makeup. Studies show that celery seed components produce a relaxing, dilating effect that lowers blood pressure. This appears to occur, at least in part, by blocking or antagonizing the flow of calcium into muscle cells lining blood vessels—similar to the action performed by calcium channel blocking drugs.^7,24,25 One key blood pressure-lowering compound in celery seeds has the technical name of L-3-n-butylphthalide, abbreviated as 3nB.^26,27

 

3nB has been used in a number of studies for the management of vascular diseases in the brain, such as stroke and vascular dementia.^26,28,29 And even now, a synthetic form of 3nB is being developed as a drug in China for the treatment of cerebral ischemic stroke and mild cognitive impairment as well as for the prevention of Alzheimer’s disease—all of which have components of abnormalities in blood flow.^26,30-33

 

Animal and lab studies reveal that 3nB-rich extracts of celery seeds produce blood pressure reductions of up to 38 mm Hg in hypertensive rats (this effect was not seen in those with normal blood pressures).²⁷ Animal studies also demonstrate that celery seed extract has no significant toxic effects even at very high doses.³⁴

 

A human study demonstrating the effectiveness of a celery seed extract standardized to 85% 3nB recently appeared in the Natural Medicine Journal.⁹ For the study, 30 middle-aged patients with mild-to-moderate hypertension took 75 mg doses of a celery seed extract twice daily for six weeks. To obtain an equivalent amount of 3nB, one would have to consume approximately 530 stalks (nearly 50 pounds) of celery. 

Mean blood pressures at baseline were 139.4/85.4 mm Hg. At three weeks, they fell to 134.8/80.9, and at six weeks they fell to 131.2/76.9. This represents total drops of 8.2 mm Hg systolic and 8.5 diastolic from baseline. 

Of great importance, while pharmacological calcium channel blockers and ACE inhibitors are known to reduce blood flow to the brain—which can leave patients feeling tired, depressed, dizzy, or forgetful—celery seed extracts rich in 3nB appear to improve brain blood flow, prevent stroke, and may protect brain cells and enhance their energy consumption.^9,30,33,35

^{Sources: http://www.lef.org/Magazine/2014/10/Two-Natural-Plant-Extracts-Lower-Blood-Pressure/Page-01}